Lose Your Head is a psycho thriller about a Spanish party tourist who gets lost in Berlin. The film is inspired by the true story of a young Portuguese man who disappeared some years ago after a night at Berghain. Like thousands of other young tourists, Luis from Madrid arrives in Berlin to spend a carefree summer weekend. After a break-up, Berlin's infamous club scene seems the ideal place to fuck the pain away, make new friends, and fall in love again. However, Luis' resemblance to a young Greek student who had gone missing a few weeks ago gets him involved in a series of mysterious events. What starts out like a romantic adventure turns into a desperate chase through the streets as Luis gets more and more lost between paranoia and reality.